ESR10 – Paola Bonaventura

ESR 10 Title: Cytokine networks in arthritis
Research Objectives:
Description of work: ULyon has had a major contribution to the field of IL-17 and Th17 cells in the context of rheumatoid arthritis (RA). ULyon identified the additional complexity of IL-17 and IL-17 receptor families, focusing on differences between IL-17A and IL-17F and the differential contribution of IL-17RA and IL-17RC as membrane receptors for IL-17A and IL-17F. ULyon indicated that IL-17 has an effect on chronicity leading to decreased apoptosis of synoviocytes. This ESR is focusing on interactions between mesenchymal cells, such as MSC and synoviocytes, and T-cell subsets. Differential effects of supernatants from Th1, Th2, and Th17 cells will be evaluated on synoviocytes followed by the same study with isolated T-cell clones. The studies will be performed at the mRNA level with arrays and qRT-PCR. Increased incidence and severity of cardiovascular events have been identified in patients with RA. In order to evaluate the systemic effect of IL-17, we are expanding the concept obtained with synoviocytes to endothelial cells. In addition to inflammation, focus will be on coagulation, platelet aggregation and thrombosis.Personal Information Sheet ESR10 – Paola BonaventuraPresentation ESR10 Paola Bonaventura